Table 5. The relationship between metal concentrations and allergen-specific IgE scores.
| Adjustedb mean (95% CI) of the metal concentration, ng/g | ||||||||
| Antigen-specific IgE classesa |
0 | 1 | 2 | 3 | 4 | 5 | 6 |
P for trendc |
| HDM | ||||||||
| Hg | 3.67 (3.63, 3.71) | 3.64 (3.61, 3.67) | 3.61 (3.57, 3.64) | 3.58 (3.53, 3.62) | 3.55 (3.49, 3.61) | 3.52 (3.44, 3.59) | 3.49 (3.39, 3.58) | 0.002 |
| JCP | ||||||||
| Hg | 3.49 (3.45, 3.54) | 3.57 (3.54, 3.61) | 3.65 (3.62, 3.69) | 3.74 (3.70, 3.78) | 3.82 (3.76, 3.88) | 3.91 (3.83, 3.99) | 4.00 (3.90, 4.10) | <0.001 |
| Se | 169 (168, 169) | 169 (169, 170) | 170 (170, 170) | 171 (170, 171) | 171 (171, 172) | 172 (171, 173) | 173 (172, 174) | <0.001 |
| Animal dander | ||||||||
| Hg | 3.66 (3.63, 3.70) | 3.58 (3.54, 3.61) | 3.49 (3.43, 3.56) | 3.41 (3.32, 3.51) | 3.33 (3.21, 3.46) | 3.25 (3.10, 3.41) | 3.18 (3.00, 3.37) | <0.001 |
| Mn | 15.2 (15.1, 15.3) | 15.1 (15.0, 15.2) | 15.0 (14.9, 15.2) | 14.9 (14.7, 15.2) | 14.9 (14.6, 15.2) | 14.8 (14.4, 15.2) | 14.7 (14.2, 15.1) | 0.033 |
CI, confidence interval; HDM, house dust mites; JCP, Japanese cedar pollen.
aclass 0: <0.35, class 1: 0.35–0.69, class 2: 0.70–3.49, class 3: 3.5–17.49, class 4: 17.5–49.99, class 5: 50–99.99, class 6: ≥100 (UA/mL).
bAge, BMI, allergic diseases (asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, food allergy, drug allergy), smoking during pregnancy, smoking habits of partner, alcohol consumption during pregnancy, owning pets, month of T1 blood sampling, and geographic region were adjusted for.
cP for trend was obtained using multivariable regression analysis with natural log transformed metal concentrations.