Table 2. Association of CHD in gout patients with multivariable analysis of Cox regression analysis.

Variables	Incident CHD (N)	Unadjusted HR	95% CI	p-value	Adjusted HR	95% CI	p-value
Total	4124
Group
Non-gout (ref.)	3155	1			1
Gout	969	1.75	1.63-1.88	< 0.001	1.34	1.23-1.45	< 0.001
Gender
Male (ref.)	3241	1			1
Female	883	1.36	1.26-1.47	< 0.001	0.86	0.79-0.93	< 0.001
Age (years)
≤ 34 (ref.)	62	1			1
35~44	286	3.42	2.60-4.50	< 0.001	3.37	2.55-4.45	< 0.001
45~54	810	6.70	5.18-8.67	< 0.001	6.45	4.96-8.37	< 0.001
55~64	1049	11.19	8.67-14.46	< 0.001	10.42	8.03-13.52	< 0.001
65~74	1257	16.56	12.84-21.37	< 0.001	16.44	12.64-21.37	< 0.001
≥ 75	660	17.01	13.11-22.06	< 0.001	14.72	11.25-19.28	< 0.001
Month insurance salary (NTD)
≤ 17,280 (ref.)	691	1			1
Dependent	1130	1.34	1.22-1.47	< 0.001	1.03	0.92-1.14	0.627
17,281~22,800	1290	1.08	0.98-1.18	0.117	1.02	0.92-1.13	0.724
≥ 22,801	1013	0.73	0.66-0.80	< 0.001	1.06	0.95-1.19	0.287
Urbanization
Level 1 (ref.)	1346	1			1
Level 2	1146	0.93	0.86-1.00	0.052	0.90	0.82-0.98	0.011
Level 3	518	0.84	0.76-0.93	0.001	0.81	0.73-0.91	< 0.001
Level 4	582	1.06	0.96-1.17	0.239	0.84	0.76-0.94	0.002
Level 5	118	1.17	0.97-1.42	0.096	0.91	0.74-1.12	0.377
Level 6	229	1.24	1.07-1.42	0.003	0.92	0.79-1.08	0.326
Level 7	185	1.16	0.99-1.35	0.06	0.92	0.77-1.09	0.332
HTN
No (ref.)	2566	1			1
Yes	1558	2.72	2.55-2.89	< 0.001	1.53	1.42-1.65	< 0.001
HPL
No (ref.)	3239	1			1
Yes	885	2.01	1.87-2.17	< 0.001	1.18	1.07-1.29	< 0.001
DM
No (ref.)	3400	1			1
Yes	724	2.23	2.06-2.41	< 0.001	1.24	1.13-1.36	< 0.001
Major illness
No (ref.)	3997	1			1
Yes	127	1.38	1.16-1.65	< 0.001	0.78	0.65-0.95	0.012

CHD, coronary heart disease; CI, confidence interval; DM, diabetes mellitus; HPT, hyperlipidemia; HR, hazards ratio; HTN, hypertension.