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. 2019 Nov 15;39(11):BSR20180896. doi: 10.1042/BSR20180896

Figure 2. Effects of LncRNA P5848 on cell proliferation, apoptosis, and migration.

Figure 2

(A) LncRNA P5848 promotes cell growth. HepG2 were heated at 50°C over 72 h, resulting in a remarkable increase in cell growth compared with other treatments. (B) LncRNA P5848 inhibits cell apoptosis, whereas knockdown of LncRNA P5848 induces apoptosis. (C) Representative blots showing the expression level of BAX, Bcl-2, Cleaved caspase-3. β-actin functions as an internal loading control. Heat exposure increases anti-apoptotic protein Bcl-2, while decreasing BAX. Knockdown of LncRNA P5848 increases the expression level of pro-apoptotic protein BAX and induces caspase-3 cleavage, while decreasing the level of anti-apoptotic protein Bcl-2. (D) LncRNA P5848 promotes cell migration, while knockdown of LncRNA P5848 inhibiting cell migration. *P<0.05, **P<0.01.