Table 1.
Mean symptoms sum-score (± SD) of all symptoms, 10 GI symptoms, the 5 most diagnostic GI symptoms, 4 cardiovascular symptoms, 4 respiratory symptoms and 4 skin complaints during the study period of 8 weeks
| Symptoms | 4 weeks of DAO supplementation | 4 weeks without DAO | |||
|---|---|---|---|---|---|
| Visit 1 Mean (± SD) |
Visit 2 Mean (± SD) |
Visit 3 Mean (± SD) |
Visit 4 Mean (± SD) |
Visit 5 Mean (± SD) |
|
| All symptoms | 19.6 (± 9.9) | 10.6 (± 7.7) | 6.6 (± 6.4) p < 0.0001 | 10 (± 8.3) | 12.5 (± 9) p = 0.002 |
| GI | 11.2 (± 7.5) | 6.1 (± 5.2) | 3.8 (± 4.4) p < 0.0001 | 6.5 (± 5.9) | 7.1 (± 5.3) p = 0.0058 |
| Diagnostic GI | 8.4 (± 5.6) | 4.8 (± 4.1) | 3.1 (± 3.4) p < 0.0001 | 5 (± 5) | 5.4 (± 4.3) p = 0.0312 |
| Cardiovascular | 3.6 (± 2.8) | 1.9 (± 2.1) | 1 (± 1.2) p < 0.0001 | 1.3 (± 1.7) | 1.8 (± 2.2) p = 0.0783 |
| Respiratory | 2.4 (± 2.7) | 1.6 (± 2) | 1.2 (± 1.6) p < 0.0001 | 1.2 (± 1.7) | 2.4 (± 2.6) p = 0.0029 |
| Skin | 2.4 (± 3.1) | 1 (± 1.5) | 0.5 (± 1) p < 0.0001 | 0.9 (± 1.6) | 1.2 (± 2.2) p = 0.1289 |
The significance of the change in symptoms over time was calculated using the Friedman test
DAO diamine oxidase, GI Gastrointestinal