Table 3.
Chest CT Scan Findings of Patients With Antineutrophil Cytoplasmic Antibody-Positive vs Antineutrophil Cytoplasmic Antibody-Negative Idiopathic Pulmonary Fibrosis in the Discovery Cohort
| Feature | ANCA-Negative | ANCA-Positive | P Value |
|---|---|---|---|
| Total No. with CT scan scored | 313 | 12 | |
| UIP, definite or possiblea | 249 (79.6) | 9 (75.0) | .72 |
| Reticulation, moderate or severeb | 249 (79.6) | 8 (66.7) | .28 |
| Traction bronchiectasis present | 307 (98.1) | 12 (100.0) | > .99 |
| Moderate or severeb | 195 (62.3) | 4 (33.3) | .07 |
| Honeycombing present | 211 (67.4) | 9 (75.0) | .76 |
| Moderate or severeb | 33 (10.5) | 4 (33.3) | .04 |
| Fibrosis, cranial-caudal distribution | .64 | ||
| Diffuse | 14 (4.5) | 1 (8.3) | |
| Lower | 288 (92.0) | 11 (91.7) | |
| Middle or upper | 11 (3.5) | 0 (0.0) | |
| Fibrosis, axial distribution | > .99 | ||
| Central | 2 (0.6) | 0 (0.0) | |
| Diffuse | 23 (7.3) | 1 (8.3) | |
| Peripheral | 288 (92.0) | 11 (91.7) | |
| Ground-glass opacity present | 29 (9.3) | 4 (33.3) | .02 |
| Consolidation present | 11 (3.5) | 0 (0.0) | > .99 |
| Nodules present | 2 (0.6) | 0 (0.0) | > .99 |
| Small airways disease present | 68 (97) | 4/4 (100) | > .99 |
CT scans of the chest evaluated for UIP pattern and specific radiographic findings pertinent to interstitial lung disease. Values are No. (%) or as otherwise indicated. See Table 1 and 2 legends for expansion of abbreviations.
a
Definite or possible UIP pattern vs inconsistent with UIP pattern.
b
Moderate or severe vs mild or none.