Table 2.
Total and Severe Exacerbation Frequency in Longitudinal Follow-Up
| GOLD Stage/Exacerbation History | Classic CB Definition |
SGRQ CB Definition |
||||
|---|---|---|---|---|---|---|
| Classic CB– |
Classic CB+ |
P Value | SGRQ CB– |
SGRQ CB+ |
P Value | |
| (n = 6,121) | (n = 1,434) | (n = 5,238) | (n = 2,290) | |||
| All | ||||||
| Exac freq (No./pt/y) | 0.36 ± 0.90 | 0.69 ± 1.26 | < .0001 | 0.31 ± 0.80 | 0.69 ± 1.29 | < .0001 |
| Severe exac freq (No./pt/y) | 0.13 ± 0.46 | 0.26 ± 0.74 | < .0001 | 0.10 ± 0.39 | 0.26 ± 0.74 | < .0001 |
| Exac freq ≥ 2/y (%) | 4.7 | 10.5 | < .0001 | 3.6 | 11.0 | < .0001 |
| Severe exac freq ≥ 1/y (%) | 3.6 | 7.4 | < .0001 | 2.9 | 7.6 | < .0001 |
| GOLD stage 0 | (n = 3,160) | (n = 428) | (n = 2,847) | (n = 741) | ||
| Exac freq (No./pt/y) | 0.16 ± 0.63 | 0.30 ± 0.72 | < .0001 | 0.15 ± 0.61 | 0.30 ± 0.78 | < .0001 |
| Severe exac freq (No./pt/y) | 0.06 ± 0.34 | 0.12 ± 0.45 | < .0001 | 0.05 ± 0.30 | 0.12 ± 0.52 | < .0001 |
| Exac freq ≥ 2/y (%) | 1.6 | 3.2 | .017 | 1.4 | 3.2 | .002 |
| Severe exac freq ≥ 1/y (%) | 1.6 | 3 | .044 | 1.2 | 3.6 | < .0001 |
| GOLD stage 1-2 | (n = 1,812) | (n = 555) | (n = 1,521) | (n = 846) | ||
| Exac freq (No./pt/y) | 0.34 ± 0.74 | 0.64 ± 1.14 | < .0001 | 0.31 ± 0.67 | 0.61 ± 1.09 | < .0001 |
| Severe exac freq (No./pt/y) | 0.11 ± 0.40 | 0.23 ± 0.68 | < .0001 | 0.09 ± 0.31 | 0.22 ± 0.69 | < .0001 |
| Exac freq ≥ 2/y (%) | 4.1 | 9.4 | < .0001 | 3.3 | 9.0 | < .0001 |
| Severe exac freq ≥ 1/y (%) | 2.7 | 6.1 | < .0001 | 2.3 | 5.7 | < .0001 |
| GOLD stage 3-4 | (n = 1,124) | (n = 445) | (n = 866) | (n = 703) | ||
| Exac freq (No./pt/y) | 0.96 ± 1.39 | 1.12 ± 1.62 | .040 | 0.84 ± 1.22 | 1.21 ± 1.70 | < .0001 |
| Severe exac freq (No./pt/y) | 0.35 ± 0.71 | 0.43 ± 0.96 | .082 | 0.30 ± 0.64 | 0.46 ± 0.93 | < .0001 |
| Exac freq ≥ 2/y (%) | 14.7 | 19.1 | .039 | 11.3 | 21.6 | < .0001 |
| Severe exac freq ≥ 1/y (%) | 10.9 | 13.3 | .189 | 9.5 | 14.1 | .005 |
Data are expressed as mean ± SD or percent. Probability values in boldface indicate significance. GOLD = Global Initiative for Chronic Obstructive Lung Disease; pt = patient. See Table 1 legend for expansion of other abbreviations.