Figure 4.

In Vivo and Ex Vivo Xenograft Fluorescence Imaging

(A) The animal model bearing both a Mel28 tumor (left) and a Mel28-PLX tumor (right) will be systemically administered with Cy5-labeled aptamer LL4A through the tail veins. (B) The two sides of tumor-bearing mice were intravenously injected with Cy5-labeled aptamer LL4A and then imaged at the indicated time points. (C) The excised Mel28 tumor (left) and Mel28-PLX tumor (right) tissues were harvested, and the fluorescence signals of tumor tissues were collected by using the IVIS Lumina II in vivo imaging system.