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. 2019 Oct 30;116(46):23106–23116. doi: 10.1073/pnas.1912188116

Table 3.

Summary of the literature on gut microbiota response after short-term antibiotic treatment

Study Exclusion criteria Treatment Observations
(49) Antibiotic use within previous 2 mo or hospitalization within previous 30 d. 10 d × 1 course 500 mg CIP twice, daily Decreased relative abundance of Firmicutes, increased relative abundance of Bacteroidetes, recovery in 4 wk.
(50) Significant medical problems. 3 d × 1 course 500 mg CIP twice, daily Overall diversity of the gut microbiota was largely restored 28 d after treatment.
(51) Antibiotic use within previous 12 mo. 5 d × 1 course 500 mg CIP twice, daily Community composition 4 wk after treatment is within the range of temporal variability of pretreatment.
(52) Antibiotic use within previous 12 mo. 6 d × 1 course 500 mg CIP twice, daily Decreased relative abundance of Proteobacteria. Diversity recovered almost fully 28 d after treatment.
(113) 3 d of vancomycin and imipenem intake 10-fold decrease in bacterial load right after treatment.