Table 1.
Top 10 genes induced by rosiglitazone in human SGBS adipocytes
| Affymetrix ID | RefSeq ID | Gene symbol | Gene | DMSO | Rosi | Fold-induction | P value |
| 7939056 | NM_003986 | BBOX1 | γ-Butyrobetaine hydroxylase 1 | 49.9 (6) | 267.5 (30) | 5.37 | 0.0000031 |
| 7923837 | NM_152491 | PM20D1 | Peptidase M20 domain containing 1 | 82.5 (9.5) | 437.4 (88.6) | 5.24 | 0.0000113 |
| 8081564 | NM_198196 | CD96 | CD96 molecule | 98.5 (13.4) | 476.6 (60.2) | 4.85 | 0.0000072 |
| 7958884 | NM_016816 | OAS1 | 2′-5′-oligoadenylate synthetase 1 | 289.2 (18.5) | 1269.4 (89.1) | 4.39 | 0.0000020 |
| 7938951 | NM_213599 | ANO5 | Anoctamin 5 | 46.9 (4.4) | 162.8 (47.9) | 3.35 | 0.0000768 |
| 8025402 | NM_139314 | ANGPTL4 | Angiopoietin-like 4 | 590 (15.2) | 1977 (87.6) | 3.35 | 0.0000010 |
| 7963545 | NM_175834 | KRT79 | Keratin 79 | 242 (5.4) | 811.1 (81.6) | 3.34 | 0.0000061 |
| 8166632 | NM_001128127 | GK | Glycerol kinase | 149.5 (30) | 492.4 (42.1) | 3.34 | 0.0000256 |
| 8054722 | NM_000576 | IL1B | Interleukin 1β | 261.5 (15.5) | 842.7 (78.6) | 3.22 | 0.0000082 |
| 8102904 | NM_021833 | UCP1 | Uncoupling protein 1 | 68.4 (14) | 198.8 (50.2) | 2.89 | 0.0001106 |
SGBS cells were differentiated to adipocytes then cultured in maintenance media without a TZD for 10 d. Vehicle (DMSO) or 1 uM rosiglitazone (Rosi) was then added for 36 h prior to RNA preparation and Affymetrix microarray analysis; n = 4 wells per condition, with mean (SD) shown, along with fold-induction and P value from Robust Multi-Array Average and Significance Analysis of Microarrays analysis.