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Schematic illustration of curvature-dependent F-actin formation around nanopillars. The F-BAR domain of FBP17 recognizes nanopillar-induced membrane curvature, while the SH3 domain of FBP17 interacts with N-WASP to promote Arp2/3-initiated F-actin polymerization. Truncated FBP17ΔSH3 recognizes nanopillar-induced membrane curvature but is not able to promote F-actin polymerization.
