Table 4.

Mixed effects model coefficients for associations between PFAAs and thyroid hormones in adjusted models after including interaction term for TPOAb status

		Time	Normal TPOAb	High TPOAb	TPOAb Interaction c
			β (95 % CI)	β (95 % CI)	(p-value)
FT4	PFUnA a	all	−0.011 (−0.087, 0.066)	−0.240 (−0.456, −0.025)*	0.049
TSH	1m-PFOS a,b	1	1.97 (0.198, 3.74)*	−0.819 (−3.13, 1.49)	0.008
		2	1.36 (0.218, 2.51)*	−1.427 (−3.32, 0.468)
		3	0.754 (−0.273, 1.78)	−2.03 (−3.88, −0.190)*
		4	0.146 (−1.40, 1.69)	−2.64 (−4.83, −0.453)*

^aEffect of PFAAs on thyroid hormones after adjusting for significant covariates in univariate models

^bSignificant interaction with time, coefficient calculated for main effect (all) and for each Timepoint (#)

^cLevel of significance (p-value) of TPOAb interaction term of normal vs. high TPOAb of the main effect (all Timepoints) using a threshold of 9 IU/mL

^*p < 0.05

^**p < 0.01 level of significance