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Liberal MR identifies a putative causal relationship between circulating levels of IL-18 and IBD that survives leave-one-out sensitivity analysis. Leave-one-out MR analysis for SNPs used as instruments for liberal MR analysis (black). Results show that this effect is not likely to be due to an individual SNP when compared to the observed effect of all SNPs (red). All SNPs in the leave one out analysis are trans-acting.
