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. 2019 May 9;28(19):3175–3187. doi: 10.1093/hmg/ddz118

Figure 2.

Figure 2

CIP overexpression in motor neurons specifically inhibits Cdk5/p25 hyperactivation in TriTg mice. (A and B) Representative in vitro kinase assays using active kinase (Cdk5) immunoprecipitated from the brain and (C and D) spinal cord of CIPTg, ALS and TriTg mice (**P < 0.001, ***P < 0.0001). (E) Immunoprecipitates were also subjected to in vitro kinase pad assays spinal cord (n = 8) and (F) brain (n = 8) of CIPTg, ALS and TriTg mice. Activity, as counts/minute, was quantified and summarized in the bar graphs (**P < 0.001; ***P < 0.0001). Data are presented as mean ± SEM.