Skip to main content
. 2019 May 9;28(19):3175–3187. doi: 10.1093/hmg/ddz118

Figure 6.

Figure 6

Motor neurons overexpression of CIP extends lifespan and improves motor function in SOD1G37R mice. (A) Kaplan–Meier log rank test for survival, showing CIP overexpression increases median survival from 163 days for SOD mouse (n = 16) to 189 days for TriTg mice (CIP/CRE+ALS, n = 35). (C and D) TriTg mice show significantly improved muscle strength on a grip strength test when compared with SOD1G37R at (C) Day 110 and (D) Day 150, but not at (B) Day 80. Values are mean ± SEM (n = 12–24 per genotype; ***P5 < 0.001, *P5 < 0.05 Mann-Whitney U-tests). (E–G) Motor neurons overexpression of CIP improves motor function SOD1G37R mice. TriTg mice have improved motor performance on the accelerating Rotarod at (G) Day 150, but not at (E) Day 80 and (F) Day 110 when compared with SOD1G37R. Values are mean ± SEM of motor performance (seconds, s) for mice still alive at each respective time point (n = 9–11) per animal per genotype at Days 60–120 and (n = 6–11) per sex per genotype at Day 105 due animals reaching end stage; *P < 0.05, **P < 0.001; Mann-Whitney U-tests).