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. 2019 May 9;28(19):3175–3187. doi: 10.1093/hmg/ddz118

Figure 8.

Figure 8

Motor neurons overexpression of CIP prevents the cell death and delays muscle pathology in TriTg mice. (A and B) CIP overexpression inhibits Bax up regulation in brain, (C and D) spinal cord and (E and F) cytochrome c release in brain and (G and H) spinal cord. TriTg mice showed significantly improved muscular atrophy. Representative images of H&E stained gastrocnemius muscle fibers at Day 150. Values are mean ± SEM (n = 4–6 per genotype; ***P < 0.001,**P < 0.01, Mann-Whitney U-tests).