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. 2019 Aug;76:49–59. doi: 10.1016/j.exphem.2019.07.004

Figure 4.

Figure 4

Mll-AF4+VEC-Cre+ aging mice have a higher proportion of CD3+ T-lymphoid cells in the spleen. (A) Experimental layout. Proportions of (B) CD11b+Gr1+, (C) B220+CD19+IgM+, (D) B220+CD19+IgM–, and (E) CD3+ cells in the peripheral blood of the control and Mll-AF4+VEC-Cre+ aged cohort at two time points. Proportions of (F) CD11b+Gr1+, (G) B220+CD19+IgM+, (H) B220+CD19+IgM–, and (I) CD3+ in the bone marrow and spleen of the control and Mll-AF4+VEC-Cre+ cohort at the end of study (18 months old). Peripheral blood counts of (J) white blood cells, (K) red blood cells, and (L) platelets of the control and Mll-AF4+VEC-Cre+ cohort at the end of study (18 months). Statistical differences were assessed using a nonparametric Mann–Whitney U test with a bilateral p value (*p < 0.05, **p < 0.01, ***p < 0.001).