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. 2019 Aug;76:49–59. doi: 10.1016/j.exphem.2019.07.004

Figure 5.

Figure 5

Mll-AF4 maintains the progenitor B-cell compartment in the spleen of aging mice and decreases the bone marrow HSC-MPP pool. Proportions of pre-pro-B cells (B220+CD19–ckit+ IL7R+CD43+CD24–IgM–); pro-B cells (B220+CD19+ckit+IL7R+CD43+CD24+IgM–); and pre-B cells (B220+CD19+ckit+IL7R+CD43–CD24+IgM–) in the (A) bone marrow and (B) spleen of the control and Mll-AF4+VEC-Cre+ cohort at the end of study (18 months). (C) Proportions of LT-HSC (LSK CD34–FLT3–IL7R–CD48–CD150+); ST-HSCs (LSK CD34+FLT3–IL7R–CD48–CD150+); MPPs (LSK CD34+FLT3–IL7R–CD48+), LMPPs (LSK FLT3+) and LK-CLPs (Lineage–ckit+/low Sca1–/low) in the bone marrow of the control and Mll-AF4+VEC-Cre+ cohort at the end of study (18 months). Statistical differences were assessed using a nonparametric Mann–Whitney U test with a bilateral p value (*p < 0.05, **p < 0.01, ***p < 0.001).