REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-Histone H3 (tri methyl K27)	Abcam	Cat# ab6002; RRID:AB_305237
Anti-Histone H3 (tri methyl K36)	Abcam	Cat# ab9050; RRID:AB_306966
Anti-Histone H3 (tri methyl K9)	Abcam	Cat# ab8898; RRID:AB_306848
Anti-Histone H3 (tri methyl K9)	Millipore	Cat# 05-1242; RRID:AB_1587136
Goat Anti-Mouse IgG H&L (Alexa Fluor® 555)	Abcam	Cat# ab150114; RRID:AB_2687594
Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)	Abcam	Cat# ab150077; RRID:AB_2630356
Chemicals, Peptides, and Recombinant Proteins
4-hydroxytamoxifen (4OHT)	Sigma	Cat# H6278
DAPI	Biolegend	Cat# 422801
Digitonin	Sigma	11024-24-1
DTT	Sigma	3483-12-3
PMSF	Sigma	329-98-6
Critical Commercial Assays
BCA Protein Assay Kit	Thermo Fisher Scientific	23225
Easy-spray source	Thermo Fisher Scientific	ES081
TMT10plex Isobaric Label Reagent Set	Thermo Fisher Scientific	90110
Deposited Data
H3K9me3 ChIP-seq data	Chandra et al., 2012	GEO:GSE38448
Hi-C data for growing and progeroid cells	McCord et al., 2013	GEO:GSE41764
Hi-C data for growing and senescent cells	Chandra et al., 2015	ENA:PRJEB8073
LaminB1 ChIP-seq data	Sadaie et al., 2013	GEO:GSE49341
Mass spectrometry data	This paper	PXD014929
Processed simulation and experimental data for generating the figures; example scripts for running the simulation model using LAMMPS	This paper	Edinburgh DataShare (https://datashare.is.ed.ac.uk/handle/10283/3381)
Experimental Models: Cell Lines
IMR90 normal human diploid fibroblasts	ATCC	ATCC Cat# CRL-7931, RRID:CVCL_0347
WI-38hTERT/GFP-RAF1-ER	Jeanblanc et al., 2012	RRID:CVCL_N806
Recombinant DNA
pLNCX2 ER:ras	Addgene, Young et al., 2009	Plasmid #67844
Software and Algorithms
BEDtools	Quinlan and Hall, 2010	https://bedtools.readthedocs.io/en/latest/
Bowtie2	Langmead and Salzberg, 2012	http://bowtie-bio.sourceforge.net/bowtie2/index.shtml
FastQC	Babraham Bioinformatics	https://www.bioinformatics.babraham.ac.uk/projects/fastqc/
Fiji distribution of ImageJ	Schindelin et al., 2012	https://imagej.net/Fiji
HiC-Pro (v2.10.0)	Servant et al., 2015	https://github.com/nservant/HiC-Pro
LAMMPS	Plimpton, 1995	https://lammps.sandia.gov
Picard tools (v1.98)	Broad Institute	http://broadinstitute.github.io/picard/
Proteome Discoverer (v1.4)	Thermo Fisher Scientific	https://www.thermofisher.com/order/catalog/product/OPTON-30795
RSEG package	Song and Smith, 2011	http://smithlabresearch.org/software/rseg/
SAMtools	Li et al., 2009	http://samtools.sourceforge.net/
Trim Galore	Babraham Bioinformatics	https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/