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Work flow of the study. ALEs-lipox were firstly prepared by incubating HSA with lipid peroxidation derived RCS (HNE, ACR and MDA) and then fully characterized by MS. The RAGE binding ability of each identified ALE was then determined by using the VC1 assay as previously reported [20]. Computation studies were then carried out to explain the factors governing the affinity of the adducted moieties and the site of interaction on adducted HSA for VC1-binding.
