Table 1.
List of the PTMs identified on the indicated Amino acid residues in the ALEs samples obtained by in vitro incubation of HSA with RCS.
| PTMs | Amino Acid residue | |
|---|---|---|
| MDA | N-propenal-Lysine(NPK) | Lys12, Lys20, Lys41, Lys162, Lys174, Lys212, Lys225, Lys233, Lys140, Lys262, Lys274, Lys281, Lys323, Lys359, Lys351, Lys372, Lys378, Lys389, Lys402, Lys414, Lys466, Lys475, Lys500, Lys525, Lys545, Lys564, Lys573, Lys574 |
| dihydropyridine-lysine(DHPK) | Lys41, Lys174, Lys225, Lys233, Lys274, Lys276, Lys313, Lys323, Lys359, Lys378, Lys389, Lys402, Lys466, Lys500, Lys519, Lys545, Lys573 | |
| N-2-pyrimidyl-ornithine (NPO) | Arg209, Arg218, Arg144, Arg145, Arg257, Arg337, Arg484 | |
| ACR | Michael Adduct (N-propanal derivative)(ACR-MA) | His39, Cys75, His128, Cys169, His338, Cys392, His510 |
| N-2-(4 hydroxy-tetrahydro-pyrimidyl) ornitine | ||
| (propane-arginine, HTPO) | Arg209, Arg257, Arg337 | |
| N,N-bispropenal-Lysine(2ACR-K-MA) | Lys41, Lys73, Lys174 | |
| N-(3-formyl-3,4-dehydro-piperidinyl) lysine(FDPK) | Lys174, Lys225, Lys233, Lys274, Lys323, Lys372, Lys378, Lys389, Lys500 | |
| HNE | Michael adduct (HNE-MA) | His105, Lys106, His242, His288, His338, Arg428 |
| Schiff Base (HNE-SB) | Lys106 | |
| Novel cyclic adduct (HNE-CY) | Arg209 | |
| 2-pentyl-pyrrole (PP) | Lys106 | |
| 2,3 dihydro-pentyl-furan (DHPF) | Cys53, His105, Cys448, Cys487 |