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Proposed mechanism for nitrosative stress in tumor cells exposed to a combination of SNO donors and H2S. The SNO donor SNO-Aryl-butanamide nitrosylates Cys generating CysNO. CysNO directly enters the cell through an amino-acid transporter (LAT). SNO-Aryl-butanamide reacts with H2S generating HSNO which freely diffuses into the cell. CysNO and HSNO nitrosylate GSH and protein thiols promoting nitrosative stress and tumor cell apoptosis.
