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. 2018 Nov 17;25:101051. doi: 10.1016/j.redox.2018.11.009

Fig. 1.

Fig. 1

Ovarian cancer specimens fall into two distinct clusters based on expression of the extracellular antioxidant GPx3. A: Hierarchical cluster analysis of antioxidant gene expression separates high grade serous adenocarcinoma patient samples into two distinct clusters (TCGA RNA sequencing data log2 transformed). B: Kaplan-Meier analysis of overall survival cluster 1 and cluster 2 patients (Log-rank Mantel-Cox test, HR: 1.20 [95% CI: 0.90–1.61]). C: Percentages of different tumor stages at diagnosis of patients in cluster 1 and cluster 2. D: High GPx3 expression is negatively associated with patient survival. TCGA RNA sequencing samples were sorted above (high) and below (low) median GPx3 expression, and stratified in Kaplan Meier plot by overall survival (Log-rank Mantel-Cox test, HR: 1.30 [95% CI: 0.97–1.75]). E: Kaplan Meier plot comparing overall survival of patients with high and low SOD2 expression. (Log-rank Mantel-Cox test, HR: 1.03 [95% CI: (0.89–1.60]).