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. Author manuscript; available in PMC: 2019 Nov 18.
Published in final edited form as: J Diabetes Mellitus. 2016 Nov 17;6(4):277–290. doi: 10.4236/jdm.2016.64029

Figure 1.

Figure 1.

Glucose homeostasis of STZ pretreated and untreated mice with adenovirus mediated expression of ANGPTL8 or GFP in the liver. (a) The expression of ANGPTL8 was determined by qPCR in the liver of STZ pretreated (+STZ) or untreated (−STZ) mice followed by Ad-ANGPTL8 or Ad-GFP administration. Beta actin was used as an internal control. (b) Serum triglycerides at the time of harvest. GTT performed in overnight fasted −STD mice (c) and +STD mice (d) 10 days after Ad-ANGPTL8 or Ad-GFP administration. Glucose levels during ITT performed in 4 hour fasted –STD mice (e) and +STD mice (f) 7 days after Ad-ANGPTL8 or Ad-GFP administration. ITT expressed as % reduction in glucose in –STD mice (g) and +STD mice (h). Data are means ± SEM; n = 4 – 5 per group. *: p < 0.05, **: p < 0.01 between ANGPTL8 and GFP control groups. 2-Way ANOVA showed p < 0.05 for (c).