Table 1 –

The PSMA-RADS version 1.0 classification schema (adapted from [8])

Definitively benign/likely benign

PSMA-RADS-1

PSMA-RADS-1A: Lesions without radiotracer uptake that are definitively benign

PSMA-RADS-1B: Lesions with radiotracer uptake that are definitively benign

PSMA-RADS-2

Low level radiotracer uptake in bone or soft tissue sites that would be atypical for metastatic PCa

Equivocal

PSMA-RADS-3

PSMA-RADS-3A: Equivocal radiotracer uptake in soft tissue lesions such as lymph nodes in a distribution typical for PCa

PSMA-RADS-3B: Equivocal radiotracer uptake in bone lesions that are not clearly benign

PSMA-RADS-3C: Lesions that would be atypical for PCa but have high levels of uptake and may represent a non-prostate malignancy

PSMA-RADS-3D: Lesions that are concerning for the presence of PCa or a non-prostate malignancy but lack radiotracer uptake

Many of the findings in the PSMA-RADS-3 category will require further work-up to definitively classify, with the nature of the work-up depending on the type of lesion [8]

Definitively cancer/likely cancer

PSMA-RADS-4

Lesions with high radiotracer uptake that would be typical for PCa but lack a definitive anatomic abnormality

PSMA-RADS-5

Lesions with high levels of radiotracer uptake and corresponding anatomic findings that are indicative of the presence of PCa

PCa = prostate cancer.