Table 1.
Transmission Model Estimates of Pertussis Incidence, Complications, and Vaccine-Related Adverse Effects 10 Years Into the Second Epoch
| Characteristic | Age Group, y | Total | |||
|---|---|---|---|---|---|
| <1 | 1–6 | 7–18 | >18 | ||
| B pertussis incidence, % decrease (95% CI) | |||||
| Infection | 96 (92–98) | 95 (91–98) | 95 (91–98) | 95 (91–98) | 95 (91–98) |
| Rate of hospitalization | 96 (91–97) | 95 (93–96) | 95 (90–98) | 96 (92–99) | 96 (95–99) |
| Infant death rate | 96 (92–98) | NA | NA | NA | NA |
| B pertussis complications, % decrease (95% CI) | |||||
| Rate of pneumonia | 95 (92–99) | 95 (92–99) | 95 (92–98) | 96 (93–99) | 96 (92–99) |
| Rate of seizures | 95 (92–99) | 95 (91–99) | NA | NA | 96 (92–99) |
| Rate of encephalopathy | 96 (92–99) | NA | NA | NA | NA |
| Vaccine-associated adverse effects, % increase (95% CI) | |||||
| Persistent, inconsolable crying | 175 (161–188) | 686 (539–833) | NA | NA | 632 (370–894) |
| Rate of fever | 811 (794–851) | 3150 (2453–3865) | NA | NA | 2917 (1642–4180) |
| Rate of seizures | 63 (53–74) | 261 (212–311) | NA | NA | 240 (152–333) |
| Rate of encephalopathy | 5.78 × 10−4 (5.59–5.87 × 10−4) | NA | NA | NA | NA |
Abbreviations: aP, acelullar pertussis; B pertussis, Bordetella pertussis; NA, not applicable.