Table 2.
Cost of Bordetella pertussis Infection Complications and Pertussis Vaccine Adverse Effects
| Variable | Cost per 100 000 (95% CI), $a | ||
|---|---|---|---|
| Acellular Strategy | Combined Strategy | Change, % | |
| Pertussis complications | |||
| Hospitalization | 1584 (1582–1587) | 71.12 (24.69–117.5) | 96 (93–98)b |
| Pneumonia | 194.4 (194.1–194.7) | 8.74 (2.667–14.82) | 94 (92–99)b |
| Seizures | 26.98 (26.94–27.02) | 1.213 (0.3678–2.059) | 96 (92–99)b |
| Encephalopathy | 9.629 (9.615–9.643) | 0.4328 (0.1287–0.7369) | 96 (92–99)b |
| Death | 135.2 (135.1–135.2) | 5.427 (1.251–9.603) | 96 (93–99)b |
| Societal cost | 46 100 (46 080–46 120) | 1850 (426.6–3275) | 96 (93–99)b |
| Total | 48 050 (48 030–48 070) | 1938 (512.7–3363) | 96 (93–99)b |
| Vaccine adverse effects | |||
| Seizures | 256.3 (256.1–256.6) | 874.5 (817.0–932.0) | 241 (218–331)c |
| Encephalopathy | NA | 9.25 (9.02–9.49) | NA |
| Total | 256.3 (256.1–256.6) | 883.8 (826.3–941.3) | 244 (223–264)c |
| Total costs | 48 310 (48 290–48 330) | 2822 (1395–4248) | 94 (91–97)b |
Abbreviation: NA, not applicable.
a
All costs are adjusted to 2012 US dollars.
b
Indicates a decrease.
c
Indicates an increase.