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. Author manuscript; available in PMC: 2019 Nov 18.
Published in final edited form as: Free Radic Biol Med. 2017 May 25;110:54–62. doi: 10.1016/j.freeradbiomed.2017.05.019

Fig. 9. Working kinetic model for mesna interactions with MPO.

Fig. 9.

Pathway A represents the typical classic peroxidase cycle. Pathway B shows the formation of MPO Compound I* and its conversion to MPO-Fe(III) through the formation of Compound II mediated by mesna.