Table 1.
The gene ontology enrichment results of upregulated genes
| Category | Term | Count | P | FDR |
|---|---|---|---|---|
| GOTERM_BP | GO:0006954~inflammatory response | 34 | 5.03×10−14 | 8.86×10−11 |
| GOTERM_BP | GO:0032496~response to lipopolysaccharide | 33 | 5.63×10−14 | 9.92×10−11 |
| GOTERM_BP | GO:0071222~cellular response to lipopolysaccharide | 23 | 3.27×10−11 | 5.76×10−8 |
| GOTERM_BP | GO:0042060~wound healing | 20 | 6.81×10−11 | 1.20×10−7 |
| GOTERM_BP | GO:0071347~cellular response to interleukin-1 | 18 | 7.11×10−11 | 1.25×10−7 |
| GOTERM_BP | GO:0045766~positive regulation of angiogenesis | 19 | 1.55×10−10 | 2.73×10−7 |
| GOTERM_BP | GO:0007155~cell adhesion | 27 | 2.98×10−10 | 5.24×10−7 |
| GOTERM_BP | GO:0030593~neutrophil chemotaxis | 14 | 4.50×10−10 | 7.94×10−7 |
| GOTERM_BP | GO:0070374~positive regulation of ERK1 and ERK2 cascade | 22 | 1.66×10−9 | 2.92×10−6 |
| GOTERM_BP | GO:1902042~negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 9 | 1.62×10−8 | 2.86×10−5 |
| GOTERM_BP | GO:0042127~regulation of cell proliferation | 23 | 2.06×10−8 | 3.62×10−5 |
| GOTERM_BP | GO:0010628~positive regulation of gene expression | 29 | 3.13×10−8 | 5.52×10−5 |
| GOTERM_BP | GO:0050900~leukocyte migration | 10 | 6.25×10−8 | 1.10×10−4 |
| GOTERM_BP | GO:0071356~cellular response to tumor necrosis factor | 16 | 3.69×10−7 | 6.49×10−4 |
| GOTERM_BP | GO:0007568~aging | 23 | 3.46×10−6 | 0.00609 |
| GOTERM_BP | GO:0042493~response to drug | 31 | 4.39×10−6 | 0.007737 |
| GOTERM_BP | GO:0030335~positive regulation of cell migration | 18 | 4.76×10−6 | 0.008396 |
| GOTERM_BP | GO:0043066~negative regulation of apoptotic process | 30 | 8.00×10−6 | 0.014103 |
| GOTERM_BP | GO:0045087~innate immune response | 20 | 8.87×10−6 | 0.015625 |
| GOTERM_BP | GO:0034097~response to cytokine | 12 | 1.55×10−5 | 0.027241 |
| GOTERM_BP | GO:0048661~positive regulation of smooth muscle cell proliferation | 11 | 1.84×10−5 | 0.032453 |
| GOTERM_BP | GO:0001525~angiogenesis | 16 | 2.10×10−5 | 0.037084 |
| GOTERM_MF | GO:0002020~protease binding | 14 | 5.26×10−6 | 0.007882 |
| GOTERM_MF | GO:0008009~chemokine activity | 8 | 1.62×10−5 | 0.02426 |
| GOTERM_MF | GO:0005125~cytokine activity | 15 | 1.83×10−5 | 0.027364 |
| GOTERM_CC | GO:0005615~extracellular space | 94 | 1.10×10−23 | 1.50×10−20 |
| GOTERM_CC | GO:0009986~cell surface | 47 | 8.98×10−13 | 1.22×10−9 |
| GOTERM_CC | GO:0005576~extracellular region | 49 | 1.53×10−11 | 2.08×10−8 |
| GOTERM_CC | GO:0070062~extracellular exosome | 109 | 2.86×10−10 | 3.89×10−7 |
| GOTERM_CC | GO:0031012~extracellular matrix | 24 | 1.84×10−8 | 2.50×10−5 |
| GOTERM_CC | GO:0009897~external side of plasma membrane | 23 | 1.99×10−7 | 2.72×10−4 |
| GOTERM_CC | GO:0045121~membrane raft | 21 | 2.97×10−6 | 0.00405 |
GO: Gene Ontology; BP: biological process; CC: cellular component; FDR: false discovery rate