Supplementary Table 2.
Semen parameters in healthy fertile men (control group) and in unilateral and bilateral varicocele patients
| Parameter | Healthy fertile men15 (n=10) | Varicocele patients14 | P | |
|---|---|---|---|---|
| Unilateral (n=17), n (%) | Bilateral (n=33), n (%) | |||
| Grade (1 or 2) | N/A | 26/31 (83.6) | 13/17 (76.4) | 0.62 |
| Grade (3 or 4) | N/A | 5/31 (16.1) | 4/17 (23.5) | |
| Sperm concentration (106/ml) | 69.90±37.65 | 26.35±25.57 | 35.51±44.86 | 0.76 |
| Sperm motility (%) | 57.1±16.0 | 40.23±17.09 | 41.76±19.78 | 0.86 |
| Normal sperm morphology (%) | 8.4±3.7 | 2.39±1.84 | 2.25±2.27 | 0.63 |
| ROS levels (RLU/s/106 sperm) | 142.7 (36.2, 337.7) | 766.2 (163.6, 3034.6) | 894.9 (149.2, 2842) | 0.75 |
| Sperm DNA fragmentation (%) | 14.4±3.9 | 12.0±8.8 | 16.4±10.1 | 0.02 |
These data were extracted from Agarwal et al., 2016,15 and Agarwal et al., 2015.14 Statistical analysis was performed between unilateral varicocele and bilateral varicocele patients. For all values, P<0.05 indicates a statistically significant difference based on the Mann–Whitney test. Sperm concentration, motility, morphology, and DNA fragmentation values are presented as mean±s.d. ROS levels are mentioned as median (25th and 75th percentiles), whereas sperm DNA fragmentation was represented as lower and upper limits. ROS: reactive oxygen species; RLU: relative light units; N/A: not available; s.d.: standard deviation