Supplementary Table 4.

Differentially expressed proteins and their abundance in bilateral varicocele group compared with fertile healthy men group

Uniprot number	Gene name	Protein name	Fertile men group		Bilateral varicocele group		NSAF ratio	Expression
			SC	Abund	SC	Abund
P50991	CCT4	T-complex protein 1 subunit delta  isoform a	2.7	VL	0	-	0.00	Unique to fertile group
Q9Y265	RUVBL1	RuvB-like 1	8.3	L	0	-	0.00	Unique to fertile group
P26641	EEF1G	Elongation factor 1-gamma	10.3	L	1.3	VL	0.15	UE
P07205	PGK2	Phosphoglycerate kinase 2	34.0	M	9.3	L	0.37	UE
P61769	B2M	Beta-2-microglobulin precursor	31.3	M	19.3	L	0.49	UE
P04279	SEMG1	Semenogelin-1 preproprotein	698.3	H	486.7	H	0.65	UE
P02751	FN1	Fibronectin isoform 3 preproprotein	476.7	H	439.3	H	0.66	UE
P12273	PIP	Prolactin-inducible protein precursor	258.3	H	185.7	H	0.67	UE
P08758	ANXA5	Annexin A5	13.7	L	31.3	M	2.14	OE
Q06830	PRDX1	Peroxiredoxin-1	13.3	L	35.3	M	2.18	OE
P32119	PRDX2	Peroxiredoxin-2	11.3	L	31.3	M	2.49	OE
P13796	LCP1	Plastin-2 isoform X2	10.0	L	33.3	M	3.13	OE
P15121	AKR1B1	Aldose reductase	6.0	VL	14.7	L	3.16	OE
P04083	ANXA1	Annexin A1	7.7	VL	22.0	M	3.23	OE
P49221	TGM4	Protein-glutamine gamma-glutamyltransferase 4	31.3	M	180.3	H	3.74	OE
Q6UWW0	LCN15	Lipocalin-15 isoform X1	0.7	VL	6.0	VL	9.70	OE
Q04760	GLO1	Lactoylglutathione lyase	1.3	VL	11.3	L	10.65	OE
P49327	FASN	Fatty acid synthase	0.7	VL	34.0	M	34.02	OE
P01833	PIGR	Polymeric immunoglobulin receptor  isoform X1	0.3	VL	30.0	VL	62.38	OE
O43278	SPINT1	Kunitz-type protease inhibitor 1  isoform 1 precursor	0.0		2.7	VL	0.00	Unique to bilateral varicocele group

VL: very low; L: low; M: medium; H: high; UE: underexpressed; OE: overexpressed; NSAF: normalized spectral abundance factor; Abund: abundance; SC: spectral count