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. 2019 Nov 15;5(4):2055217319888767. doi: 10.1177/2055217319888767

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Changes in gut microbial serum biomarkers of inflammation after intervention with dimethyl fumarate (DMF). In the DMF group an increase of gut microbial serum biomarkers of inflammation (a) sCD25 and (b) sCD163 were observed. In the injectable group an increase of (c) sCD25 was observed, but no change in (d) sCD163. A negative correlation was observed between (e) the increase of Firmicutes after two weeks and the increase of sCD163 after four weeks and (f) between Faecalibacterium and sCD163, i.e. patients with higher increase of Firmicutes or Faecalibacterium after two weeks had lesser increase of the inflammatory biomarkers sCD25 or sCD163 after four weeks. Wilcoxon matched pair tests including individuals with available data at both timepoints and Spearman rank correlation tests.