Table 3.

Changes in selected microbiota profile parameters from baseline.

	DMF							Injectable
	Baseline	2 weeks	p	QFDR	12 weeks	p	QFDR	Baseline	2 weeks	p	QFDR	12 weeks	p	QFDR
Actinobacteria	0.016(0.01–0.03)	0.011(0.005–0.02)	0.03	0.24	0.016(0.01–0.04)	0.78	0.86	0.027(0.01–0.05)	0.024(0.02–0.04)	1	0.95	0.02(0.008–0.03)	0.30	0.62
Bifidobacterium	0.011(0.004–0.02)	0.007(0.001–0.01)	0.06	0.69	0.012(0.002–0.02)	0.83	1	0.021 (0.005–0.04)	0.015(0.004–0.03)	0.82	0.96	0.011(0.004–0.03)	0.16	0.58
Firmicutes	0.569(0.51–0.75)	0.63(0.52–0.77)	0.50	0.71	0.679(0.56–0.78)	0.02	0.09	0.63(0.51–0.74)	0.589(0.53–0.73)	0.91	0.95	0.659(0.46–0.72)	1	0.95
Bacteroidetes	0.272 (0.18–0.43)	0.195(0.15–0.44)	0.73	0.85	0.246(0.13–0.35)	0.01	0.09	0.319(0.21–0.43)	0.359 (0.21–0.45)	0.50	0.79	0.292(0.23–0.49)	1	0.95
Faecalibacterium	0.039(0.03–0.07)	0.055(0.03–0.09)	0.13	0.69	0.067(0.04–0.11)	0.01	0.48	0.07(0.05–0.12)	0.06(0.04–0.10)	0.25	0.70	0.06(0.05–0.08)	0.30	0.58
Bacteroides	0.15 (0.10–0.32)	0.14 (0.09–0.30)	0.81	0.92	0.14 (0.07–0.23)	0.01	0.67	0.142(0.08–0.22)	0.117(0.09–0.24)	0.91	0.99	0.165(0.09–0.28)	0.82	0.86
Clostridium(sensu stricto)	9 × 10–5(0–9 × 10–4)	9 × 10–5(0–0.001)	0.66	0.86	5 × 10–5(0–7 × 10–4)	0.75	0.89	0(0–7 × 10–4)	0(0–1 × 10–4)	0.88	0.97	2 × 10–4(0–4 × 10–4)	0.63	0.77
Escherichia–Shigella	2 × 10–4(0–0.001)	9 × 10–5(0–9 × 10–4)	0.63	0.86	0(0–0.001)	0.30	0.69	0(0–4 × 10–4)	0(0–4 × 10–4)	0.34	0.73	2 × 10–4(0–0.002)	0.03	0.58

DMF: dimethyl fumarate.

Wilcoxon matched pair tests including individuals with available data at both timepoints. Corrected with Benjamini Hochberg false discovery rate (FDR).