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. 2019 Nov 18;30(Suppl 8):viii16–viii22. doi: 10.1093/annonc/mdz384

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© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Patterns of immunohistochemical staining in NTRK fusion-positive tumours. (A) Secretory carcinoma of the salivary gland with an ETV6-NTRK3 fusion shows weak to moderate nuclear and cytoplasmic staining. (B) Intrahepatic cholangiocarcinoma with a PLEKHA6-NTRK1 fusion shows prominent membranous staining. (C) Gallbladder adenocarcinoma with an LMNA-NTRK1 fusion shows strong cytoplasmic and perinuclear staining. (D) Metastatic thyroid carcinoma to soft tissue with a TPM3-NTRK1 fusion shows strong cytoplasmic and membranous staining.