Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec;26(12):485–492. doi: 10.1101/lm.050278.119

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Butler et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 1. — Effect of exercise on long-term object location memory. (A) Experimental schematic. Mice were given access to a running wheel for 2 d, 1, 2, or 3 wk prior to object location memory (OLM) behavioral training and testing. OLM testing was performed 24 h after training, and mice were returned to standard home cages overnight. Mice were habituated to the OLM chamber for 6 d prior to OLM training regardless of exercise regime. A sedentary group of mice was also included that had no access to running wheels. (B) The mean total distance run by mice in each experimental group. (C): Mean time spent attending to objects during OLM training. There was no difference between the groups. (D) Mean discrimination index for each group during OLM training. Mice showed no preference for objects during training. (E) Mean time spent attending to objects during OLM testing. There was no difference between the groups. (F) Mean discrimination index for each group during OLM testing. Mice that had no running wheel access showed no object location memory at 24 h. Mice that had run for either 2 or 3 wk showed a significant increase in object location discrimination index compared to the No exercise control group. Significant between-group comparisons are denoted by ***/****. Significant comparisons between Test discrimination index (DI) and Training DI are denoted by ####. All data shown is mean ± SEM. (***) P < 0.001, (****/####) P < 0.0001.