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. 2019 Nov 7;10:2575. doi: 10.3389/fimmu.2019.02575

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Copyright © 2019 Li, Li, Qin, Du, Li, Yuan, Han and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Siglec-G orchestrates TLR4-induced STAT3 and HIF1α activation via Src. (A,B) Immunoblotting of cell lysates from Siglecg^+/− and Siglecg^−/− peritoneal macrophages or RAW264.7 cells overexpressing CA-Src stimulated with LPS (100 ng/ml) for indicated time with indicated antibodies. (C) ELISA of IL-6, TNF-α, and IL-10 in supernatant from constitutively active Src (CA-Src) overexpressing RAW264.7 cells stimulated with LPS (100 ng/ml) for 12 h. Data are representative of three independent experiments with similar results as means ± SD. ^*P < 0.01. TLR, toll-like receptor; LPS, lipopolysaccharide; IL, interleukin; TNF-α, tumor necrosis factor-α.