Table 1. Clinical trials on the use of bacteriophages to treat bacterial infections.

Indication	Study type	Result	Reference
Chronic venous leg ulcers	Monocentric, placebo-controlled phase-I study	No evidence of relevant side effects	Rhoads et al., 2009 (e14)
Chronic otitis due to multidrug-resistant Pseudomonas aeruginosa	Monocentric, randomized, double-blind, placebo-controlled phase-I/-II study	– No evidence of relevant side effects – Significant symptom reduction in the treatment arm	Wright et al., 2009 (e15)
Burn wounds colonized with Staphylococcus aureus and Pseudomonas aeruginosa	Monocentric, placebo-controlled phase-I study	No evidence of relevant side effects	Rose et al., 2014 (e16)
Escherichia coli–associated diarrhea in childhood	Monocentric, placebo-controlled phase-II study	– No evidence of relevant side effects – No significant symptom reduction in the treatment arm	Sarker et al., 2016 (e17)
Chronic rhinosinusitis due to Staphylococcus aureus	Open-label phase-I study	– No evidence of relevant side effects – Microbial and clinical response in 22.2 % of treated patients (2/9)	Ooi et al., 2019 (e18)