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. Author manuscript; available in PMC: 2019 Nov 18.
Published in final edited form as: Nature. 2019 Mar 6;567(7748):389–393. doi: 10.1038/s41586-019-0998-5

Extended Data Fig. 3 |. Structure of full-length chicken STING in the apo state.

Extended Data Fig. 3 |

a, Side view of the cryo-EM 3D reconstruction. The two subunits in the dimer are coloured in yellow and green. b, Cartoon representation of the structure in two orthogonal side views. c, Cartoon representation of the transmembrane domain dimer in the top view, from the cytosolic side. d, Interactions between the N-terminal segment and the body of chicken STING. e, Sequence alignment of STING from human, mouse and chicken (denoted by h-, m- and ch- prefixes, respectively). Secondary structure assignments are based on the structures. Residue numbers of human and chicken STING are shown above and below the aligned sequences, respectively.