Skip to main content
. Author manuscript; available in PMC: 2019 Nov 18.
Published in final edited form as: Nature. 2019 Mar 6;567(7748):389–393. doi: 10.1038/s41586-019-0998-5

Extended Data Fig. 5 |. Additional mutational analyses of the transmembrane–LBD connector of human STING.

Extended Data Fig. 5 |

a, c, Effects of mutations in the connector and LBDα1 on cGAMP-stimulated IFNβ expression. Data are mean ± s.d. and representative of three biological replicates. b, d, Effects of STING mutations on phosphorylation of STING, TBK1 and IRF3. The result is representative of two independent experiments. The analyses for gene expression in a, c and phosphorylation in b, d were carried out in the same manner as in Fig. 2c and 2d, respectively.

HHS Vulnerability Disclosure