Table 2. Outcomes for different PCA3 thresholds.

Study	Threshold	Threshold relevance
[37]	50	Identification of men at high risk of harboring significant PCa who are candidates for RP
[39]	47	Providing a correlation between PCA3 score and tumor volume
[34, 38]	35	Optimal balance between sensitivity of 58% and specificity of 72%
[36]	35	Increased risk of PCa
[41]	35	Optimal balance with sensitivity of 54% and specificity of 74%
[40]	24 and 35	Independent predictors in multivariable intermediate-and high-grade disease models
[42]	25	Predictive of pathological indolent PCa
[43]	25	Optimal balance between sensitivity and specificity, and also NPV is greater enhanced
[44]	25	Effective to determine which men are candidates for AS
[37]	20	Selecting men with clinically insignificant PCa in whom AS may be appropriate
[45]	17	Increment in PA to detect PCa

Abbreviations: RP: radical prostatectomy; PCa: prostate cancer; NPV: negative predictive value; AS: active surveillance: PA: predictive accuracy.