Table 5. Summary of reporting of TMB testing practices reported by 81 included publications.

Genes tested, n (%)	27 (33%) [10, 30, 32–36, 39–41, 44, 46, 48, 55, 63, 70, 71, 73–75, 86, 87, 91, 94, 100, 101, 104]
Median (range) reported values	315 (15–592)
Mbs tested, n (%)	10 (12%) [16, 33, 40, 45, 54, 63, 70, 71, 81, 84]
Median (range) reported values	1.1 (0.8–1.2)
Units used for TMB measurement, n (%)
Mut/Mb	37 (46%) [16, 28, 30, 33–35, 37, 40, 41, 45, 46, 48, 54, 60, 61, 63, 66, 67, 69–87]
Total mutations	34 (42%) [1, 10, 32, 36, 38, 39, 42–44, 47, 49–51, 53, 55–57, 59, 62, 64, 65, 68, 88–99]
Both	2 (2%) [31, 100]
Other units	8 (10%) [27, 29, 52, 101–105]
TMB threshold defined, n (%)	33 (41%) [1, 10, 16, 28, 30, 32–37, 39, 41–44, 48, 51, 54–56, 60, 63, 66, 69–71, 75, 84, 86, 91, 99, 102]
By mut/Mb	16 (48%) [16, 28, 33, 35, 37, 41, 48, 54, 63, 66, 69–71, 75, 84, 91]
Median (range) reported values	20 (10–20)
By percentiles	10 (30%) [1, 30, 34, 36, 44, 51, 56, 60, 86, 99]
Median (range) reported values	50 (50–85)
By total mutations	6 (18%) [10, 32, 39, 42, 43, 55]
Range of reported values	4–242

Abbreviations: mut/Mb, mutations per DNA megabase; TMB, tumor mutational burden.