Table 4. Translational studies demonstrating effects on tumor microenvironment of BRAF and MEK inhibitors.

Class of Drugs	Effect on microenvironment	Type of cancer	Model	ref
BRAFi, MEKi	Increase of Melanocyte Differentiation Agents	Melanoma	Bioptic samples of treated patients	Frederick et al.
BRAFi	Reduction of MDSCs	Melanoma	Serum of treated patients	Schilling et al.
BRAFi	Increased intratumoral CD8+ T cells	Melanoma	Bioptic samples of treated patients	Wilmott et al. Frederick, et al.
BRAFi	CXCL8 lowering	Melanoma	Serum of treated patients	Willmott et al.