Genetic environments of Tn1999 within pOXA-48a, Tn1999.2 in pOXA-48_4963, inverted Tn1999.2 in pRA35, and Tn6237 containing inverted ΔTn1999.2 in the E. coli chromosome. In the E. coli EC15 chromosome, Tn6237 was inserted into a gene coding histidine kinase-like ATPase (ECP4571 in E. coli 536 [GenBank accession number CP000247]). Mobile elements are indicated with black (e.g., IS1999) or gray (others). Genes from background plasmids are indicated with cyan, and those from the chromosome are indicated with green. Yellow triangles indicate target site duplications.