Table 3.
Multivariate analysis of annualized percent change in standardized bone mineral density
| Parameter | Estimate | CI | p-Value |
|---|---|---|---|
| GC withdrawal | |||
| Lumbar spine | 4.55 | 3.11, 5.99 | <0.0001 |
| Total hip | 2.22 | 0.70, 3.74 | 0.004 |
| Femoral neck | 1.63 | 0.14, 3.12 | 0.032 |
| GC continuation | |||
| Lumbar spine | 0.91 | −0.57, 2.40 | 0.227 |
| Total hip | −0.22 | −1.81, 1.38 | 0.791 |
| Femoral neck | 1.45 | −0.087, 2.98 | 0.064 |
| Effect of GC | |||
| Lumbar spine | −3.63 | 5.72, −1.55 | 0.001 |
| Total hip | −2.44 | −4.65, −0.22 | 0.031 |
| Femoral neck | −0.18 | −2.33, 1.97 | 0.868 |
| Per U/L change in alkaline phosphatase | 0.033 | 0.012, 0.055 | 0.003 |
| Per 0.100 g/cm2 change in baseline BMD | −0.69 | −1.33, −0.046 | 0.036 |
| Per 1 mL/min change in creatinine clearance | 0.036 | 0.00, 0.071 | 0.047 |
BMD, bone mineral density; GC, glucocorticoid.