Table 4.
Univariate and Multivariate Analyses of Risk Factors for Postoperative Overall Morbidity of Elderly Patients with Periampullary Neoplasms
| Variable | Total (n=154) | Overall morbidity | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|---|
|
|
|
|
|||||
| Negative (n=90) | Positive (n=64) | HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Age ≥75 yr | 37 (24.0) | 23 (25.6) | 14 (21.9) | 0.82 (0.38–1.74) | 0.599 | ||
| Male sex | 80 (51.9) | 44 (48.9) | 36 (56.3) | 1.34 (0.71–2.56) | 0.368 | ||
| Nutritional status (at risk or malnourished) | 134 (87.0) | 74 (82.2) | 60 (93.8) | 3.24 (1.03–10.2) | 0.044* | 3.45 (1.10–11.09) | 0.037* |
| ASA, grade II | 109 (70.8) | 66 (73.3) | 43 (67.2) | 0.74 (0.37–1.50) | 0.409 | ||
| Preoperative diabetes mellitus | 46 (29.9) | 26 (28.9) | 20 (31.3) | 1.12 (0.56–2.25) | 0.752 | ||
| Type of surgery, PPPD | 135 (87.7) | 76 (84.4) | 59 (92.2) | 2.46 (0.79–7.60) | 0.117 | ||
| Malignancy (malignant) | 122 (79.2) | 68 (75.6) | 54 (84.4) | 1.75 (0.76–4.00) | 0.187 | ||
| Pancreatic texture, soft | 112 (72.7) | 66 (73.3) | 46 (71.9) | 1.00 (0.45–2.22) | 0.986 | ||
| Intraoperative blood loss, mL | 350±266 | 309±184 | 407±343 | 1.00 (1.00–1.03) | 0.045* | 1.01 (1.00–1.03) | 0.040* |
| Operation time, min | 305±90 | 297±78 | 317±103 | 1.00 (0.99–1.01) | 0.998 | ||
| Pancreatic duct diameter, <3 mm | 63 (40.9) | 39 (43.3) | 24 (37.5) | 1.20 (0.58–2.46) | 0.613 | ||
Data are presented as the number (%) or mean±SD.
HR, hazard ratio; CI, confidence interval; ASA, American Society of Anesthesiologists physical status; PPPD, pylorus-preserving pancreatoduodenectomy.
*
Significantly different.