Table 2.
Leg cramps after treatment, side effects and returned drug
| Treatment group (n = 43) | Placebo group (n = 43) | P value | |
|---|---|---|---|
| 50% reduction of number | 37 (86.0%) | 26 (60.5%) | 0.007* |
| of leg cramps | (75.6, 96.3) | (45.8, 75.1) | |
| 50% reduction of pain score | 30 (69.8%) | 21 (48.8%) | 0.04* |
| of leg cramps | (56, 83.5) | (33.8, 63.7) | |
| Mean percentage change of number of leg cramps (95%CI) | 79 (70.2, 87.8) | 32.4 (3.4, 61.5) | 0.003 ‡ |
| Median absolute change of number of leg cramps (interquartile range) | 1 (0, 4) | 3 (2, 7) | 0.003 § |
| Median absolute change of pain score of leg cramps (interquartile range) | 34 (16, 54) | 53 (10, 71) | 0.16 § |
| Total cases without leg cramp | 21 (48.8%) | 12 (27.9%) | 0.04* |
| (33.8, 63.7) | (14.4, 41.3) | ||
| Side effects | |||
| Nausea | 11 (25.6%) | 6 (14.0%) | 0.27* |
| (12.5, 38.6) | (3.6, 24.3) | ||
| Diarrhoea | 6 (14.0%) | 1 (2.3%) | 0.10 † ; |
| (3.6, 24.3) | (0, 6.7) | ||
| Mean tablets of returned drug | 11.3 ± 10.9 | 14.3 ± 11.4 | 0.26 ‡ |
CI, confidence interval. Data present as mean ± standard deviation or n (%) (95% CI). *Chi‐squared test, †Fisher's exact test, ‡Independent t‐test and §Mann–Whitney U‐test were used.