Table 3. Preterm birth @<32 weeks’ gestation (n = 107573).

Prescriptions	Exposed n [%]	Unexposed n [%]	Unadjusted OR [95% CI	Adjusted* OR [95% CI]	Interaction term with depression variable
SSRI [any N06AB] in trimesters 2 or 3	20/1625 [1.23]	913/105,948 [0.86]	1.43 [0.92–2.24]	1.24 [0.76–2.03]	1.04(0.39–2.81)
SSRI high dose in trimesters 2 or 3	7/538 [1.3]	926/107035 [0.87]	1.51 [0.72–3.19]	1.74 [0.55–5.46]	0.69[0.17–2.82]
Antidepressant [any N06A] in trimesters 2 or 3	23/2043 [1.13]	910/105,530 [0.86]	1.31 [0.86–1.99]	1.15 [0.73–1.81]	1.31(0.73–2.34)
SSRI in trimester 1 but not in trimesters 2 or 3	25/2285 [1.09]	908/105288 [0.86]	1.27 [0.85–1.90]	0.88 [0.48–1.60]	1.09[0.54–2.20]
Antidepressant in trimester 1 but not in trimesters 2 or 3	48/4252 [1.13]	885/103,321 [0.86]	1.32 [0.99–1.77]	1.11 [0.80–1.55]	0.85[0.44–1.65]
Depression unmedicated	127/11,700 [1.09]	806 [0.84]	1.29 [1.07–1.56]	1.29[1.05–1.58]	na
Depression medicated	15/1048 [1.43]	918/10,652 [0.86]	1.67[1.00–2.79]	1.63 [0.94–2.84]	na
Depression diagnosed	139–142**/12,748 [1.09–1.11]	791/94,034 [0.84]	OR> 1 statistically significant	1.33 [1.09–1.62]	na

Exclusions, definitions and abbreviations as in Table 2

*Adjusted for parity, smoking, socio-economic status [SES] as Townsend fifth [quintile].

NNH for depression diagnosed and unmedicated 409 [227–2070].

** Numbers have been blurred to avoid revealing a number <5 in another cell.