Table 6. Breastfeeding at 6–8 weeks (n = 38725).
Exposures | Exposed n [%] | Unexposed [n [%] | Unadjusted OR [95% CI] |
Adjusted* OR [95% CI] | NNH | Interaction term with depression variable |
---|---|---|---|---|---|---|
SSRI [any N06AB] in trimesters 2 or 3 | 137/645 [21.24] | 12,656/38,080 [33.24] | 0.54 [0.45–0.66] | 0.77 [0.62–0.95] | 9 [7–12] | 1.11(0.72–1.70) |
SSRI high dose in trimesters 2 or 3 | 47/214 [21.96] | 12,746/38,511 [33.1] | 0.57 [0.41–0.79] | 0.45 [0.23–0.86] | 9 [6–18] | 2.49[11.13–5.52] |
Antidepressant [any N06A] in trimesters 2 or 3 | 179/806 [22.21] | 12,614/37,919 [33.27] | 0.57 [0.48–0.68] | 0.81 [0.67–0.98] | 10 [8–13] | 1.25[0.86–1.83] |
SSRI in trimester 1 but not in trimesters 2 or 3 | 207/862 [24.02] | 12,586/37,863 [33.24] | 0.64 [0.54–0.74] | 0.66 [0.51–0.87] | 11 [9–16] | 1.59[1.10–2.30] |
Antidepressant in trimester 1 but not in trimesters 2 or 3 | 376/1619 [23.22] | 12,417/37,106 [33.46] | 0.60 [0.54–0.68] | 0.70 [0.57–0.85] | 10 [9–13] | 1.37[1.04–1.80] |
Depression diagnosed and unmedicated in t2 and t3 | 1365/5241 [25.87] | 11,428/33,484 [34.13] | 0.68 [0.67–0.73] | 0.87 [0.82–0.92] | 13 [11–15] | Na |
Depression medicated in t2 or t3 | 102/472 [21.62] | 12,691/38,253 [33.18] | 0.56 [0.45–0.69] | 0.70 [0.58–0.85] | 9 [7–13] | Na |
Depression diagnosed | 1467/5713 [25.7] | 11,346/33,012 [34.31] | 0.66 [0.62–0.71] | 0.76 [0.70–0.82] | 12 [11–14] | Na |
Exclusions, definitions and abbreviations as in Table 2
*Adjusted for SES, as Townsend fifth, parity, smoking and year of birth.