To date, the Innovation and Value Initiative has released two flexible open-source economic models that are developed iteratively based on public feedback and input—one focused on rheumatoid arthritis and one focused on epidermal growth factor receptor-positive non-small-cell lung cancer

Models were developed in R along with web-based user interfaces because we are of the opinion that it has advantages in terms of transparency, reproducibility, modifiability, and computational efficiency over using spreadsheet software

Development of the rheumatoid arthritis and non-small-cell lung cancer models has presented multiple challenges, particularly related to the development of multiple components that characterize the platforms, methodological aspects, and iterative development based on public feedback

In the health economics and modeling community, there is a growing discussion about transparency and open-source model development, and the models developed by the Innovation and Value Initiative seem to be recognized as a welcome effort