Table 5.
Pregnancy outcome data
| Characteristics | Pregnancy outcome | P value | |||
|---|---|---|---|---|---|
| Normal | Pre‐eclampsia | IUGR | Other* | ||
| n | 63 | 15 | 21 | 38 | |
| Maternal age | 33 (32–35) | 35 (31–39) | 31 (27–34) | 33 (31–36) | 0.312 |
| BMI (kg) | 27 (26–28) | 32 (27–37) | 28 (25–31) | 29 (27–32) | 0.100 |
| Smokers | 5 (7.2%) | 5 (33.3%) c | 7 (33.3%) c | 4 (10.5%) | 0.003 |
| Birthweight | 3680 (3552–3755) | 2523 (2050–2996) a | 2518 (2092–2945) a | 3158 (2931–3385) b | <0.001 |
| Growth centile † | 60 (53–66) | 23 (9–37) a | 22 (8–36) a | 57 (48–67) | <0.001 |
| Gestational age | 277 (275–278) | 251 (235–266) a | 254 (238–268) a | 262 (255–268) b | <0.001 |
| Blood micronutrients | |||||
| Hcy µmol/L | 4.2 (3.9–4.4) | 4.8 (3.9–5.8) | 5.3 (4.6–6.2) a | 4.8 (4.3–5.4) | 0.007 |
| RBC folate nmol/L | 690 (640–740) | 664 (521–807) | 481 (379–582) a | 680 (598–762) | 0.003 |
| Serum folate nmol/L | 26.6 (25–29) | 29.6 (24–35) | 21.1 (17–26) b | 28 (25–32) | 0.024 |
| Serum B12 pmol/L | 243 (209–277) | 319 (200–438) | 205 (182–262) | 222 (182–262) | 0.109 |
| RBC B6% ‡ | 41.9 (38–46) | 41.5 (29–54) | 50.0 (45–55) | 38.0 (33–44) | 0.062 |
Values are mean (95% confidence interval) or numbers (percentage) calculated using analysis of variance and chi‐squared analyses. BMI, body mass index; IUGR, intrauterine growth restriction; RBC, red blood cell; *Other: All other adverse pregnancy outcomes not including pre‐eclampsia or IUGR. †Birthweight centiles indicates birthweight according to gestation, maternal height, weight, ethnicity, parity and sex of the baby. ‡Based on pyridoxal phosphate activation activity that is inversely related to vitamin B6 concentration. a P < 0.001 compared with normal pregnancy outcome; b P < 0.01 compared with normal pregnancy outcome; c P < 0.05 compared with normal pregnancy outcome. Bold indicates P values that are significant (P < 0.050).