Table 2.
Regression coefficients from analyses of long n‐6 and n‐3 fatty acid levels as a percentage of total fatty acid levels in red blood cell lipids on FADS SNPs in 6711 blood samples from 4457 pregnant women
| FADS1 | Intergenic | FADS2 | |||||
|---|---|---|---|---|---|---|---|
| rs174548 | rs174556 | rs174561 | rs3834458 | rs968567 | rs174570 | rs174574 | |
| Omega‐6 | |||||||
| 18:2 | 0.110 (0.020)*** | 0.112 (0.020)*** | 0.108 (0.020)*** | 0.106 (0.019)*** | 0.018 (0.024) | 0.150 (0.027)*** | 0.113 (0.019)*** |
| 20:4 | −0.154 (0.021)*** | −0.151 (0.021)*** | −0.155 (0.021)*** | −0.151 (0.020)*** | −0.131 (0.025)*** | −0.129 (0.029)*** | −0.147 (0.020)*** |
| Omega‐3 | |||||||
| 18:3 | 0.079 (0.021)*** | 0.084 (0.021)*** | 0.081 (0.021)*** | 0.075 (0.020)*** | 0.013 (0.025) | 0.071 (0.028)* | 0.073 (0.020)*** |
| 20:5 | −0.074 (0.021)*** | −0.069 (0.021)** | −0.074 (0.021)*** | −0.075 (0.021)*** | −0.091 (0.026)*** | −0.037 (0.029) | −0.068 (0.020)*** |
| 22:6 | −0.092 (0.021)*** | −0.092 (0.021)*** | −0.096 (0.021)*** | −0.097 (0.020)*** | −0.089 (0.025)*** | −0.073 (0.028)** | −0.092 (0.020)*** |
| Ratios | |||||||
| AA to LA | −0.262 (0.021)*** | −0.259 (0.021)*** | −0.262 (0.021)*** | −0.256 (0.020)*** | −0.175 (0.025)*** | −0.255 (0.028)*** | −0.254 (0.020)*** |
| EPA to ALA | −0.165 (0.020)*** | −0.165 (0.020)*** | −0.166 (0.020)*** | −0.161 (0.020)*** | −0.111 (0.025)*** | −0.117 (0.028)*** | −0.151 (0.019)*** |
| N | 6565 | 6524 | 6560 | 6558 | 6666 | 6583 | 6554 |
| FADS2 | |||||||
|---|---|---|---|---|---|---|---|
| rs2727271 | rs174576 | rs174578 | rs174579 | rs174602 | rs498793 | rs526126 | |
| Omega‐6 | |||||||
| 18:2 | 0.155 (0.028)*** | 0.108 (0.019)*** | 0.111 (0.019)*** | 0.053 (0.022)* | 0.080 (0.023)*** | −0.025 (0.018) | −0.011 (0.024) |
| 20:4 | −0.114 (0.030)*** | −0.144 (0.020)*** | −0.146 (0.020)*** | −0.120 (0.023)*** | −0.037 (0.024) | 0.041 (0.020)* | −0.079 (0.025)** |
| Omega‐3 | |||||||
| 18:3 | 0.123 (0.030)*** | 0.069 (0.020)*** | 0.070 (0.020)*** | 0.028 (0.023) | 0.063 (0.024)** | 0.007 (0.019) | −0.008 (0.025) |
| 20:5 | −0.017 (0.030) | −0.064 (0.021)** | −0.064 (0.020)** | −0.066 (0.023)** | −0.012 (0.024) | 0.031 (0.020) | −0.067 (0.025)** |
| 22:6 | −0.052 (0.030) | −0.091 (0.020)*** | −0.093 (0.020)*** | −0.088 (0.023)*** | −0.034 (0.024) | 0.045 (0.019)* | −0.092 (0.025)*** |
| Ratios | |||||||
| AA to LA | −0.241 (0.030)*** | −0.248 (0.020)*** | −0.252 (0.020)*** | −0.183 (0.023)*** | −0.096 (0.024)*** | 0.065 (0.020)*** | −0.093 (0.025)*** |
| EPA to ALA | −0.152 (0.029)*** | −0.144 (0.020)*** | −0.144 (0.019)*** | −0.101 (0.022)*** | −0.082 (0.023)*** | 0.026 (0.019) | −0.063 (0.024)** |
| N | 6569 | 6481 | 6574 | 6556 | 6591 | 6555 | 6595 |
| Intergenic | FADS3 | ||
|---|---|---|---|
| rs174448 | rs174449 | rs174455 | |
| Omega‐6 | |||
| 18:2 | 0.070 (0.019)*** | 0.065 (0.019)*** | 0.059 (0.019)** |
| 20:4 | −0.095 (0.020)*** | −0.103 (0.020)*** | −0.099 (0.020)*** |
| Omega‐3 | |||
| 18:3 | 0.043 (0.020)* | 0.043 (0.020)* | 0.032 (0.020) |
| 20:5 | −0.043 (0.020)* | −0.050 (0.020)* | −0.051 (0.021)* |
| 22:6 | −0.076 (0.020)*** | −0.082 (0.020)*** | −0.062 (0.020)** |
| Ratios | |||
| AA to LA | −0.164 (0.020)*** | −0.169 (0.020)*** | −0.160 (0.020)*** |
| EPA to ALA | −0.093 (0.019)*** | −0.101 (0.020)*** | −0.088 (0.020)*** |
| N | 6623 | 6583 | 6569 |
Modified from Koletzko et al. (2011). Fatty acids and ratios have been standardized to have a variance of one. Standard errors are reported in parentheses. *P < 0.05, **P < 0.01, ***P < 0.001. AA, arachidonic acid; EPA, eicosapentaenoic acid; FADS, fatty acid desaturase; LA, linoleic acid; SNPs, single nucleotide polymorphisms; FADS1, fatty acid desaturase 1; FADS2, fatty acid desaturase 2; FADS3, fatty acid desaturase 3; ALA, alpha‐linolenic acid.